CD4 - CD8 COUNT AND TREATMENT

 

       WHAT IS CD4 - CD8 COUNT?

CD4 and CD8 are two types of white blood cells in your blood. CD4 cells are also called T-helper cells, T-suppressor cells, and cytotoxic T-cells. They help the body fight infections. 

CD8 cells are also called cytotoxic T-lymphocytes. They help fight cancer and germs that live inside your cells (intracellular pathogens). 

The human immunodeficiency virus (HIV) chiefly targets CD4 cells. A reduced number of these cells and a change in the CD4:CD8 ratio are signs of HIV infection. The CD4:CD8 ratio helps your physician judge disease activity and your response to treatment.

CD4 Cell Count

The CD4 cell count is a good measure of the activity of the HIV infection and the success of the treatment. Normal CD4 numbers in the blood range between 500 to 1200 per cubic millimeter. 

The normal range for CD8 is 150 to 1000 per cubic millimeter. A CD4:CD8 ratio of more than 1.0 is considered normal. 

A CD4 count below 200 per cubic millimeters shows that you have acquired immunodeficiency syndrome (AIDS). Low CD4 counts are also seen in bone marrow suppression because of chemotherapy, long-standing infections, and some types of anemia.

Once you start ART (antiretroviral therapy, a combination of antiviral medicines), your CD4 cell count increases gradually. Your physician will get your CD4 count tested every 3 to 6 months. The return of the CD4 count to normal levels (500 per cubic millimeter) is a sign that the HIV infection is under control.

High CD8 Counts

Your doctor monitors CD8 counts frequently while you are on treatment for HIV. If your CD8 count is high, it means your viral load is low. Your CD4 count is likely to return to normal levels. CD8 cells are important in the body's defense against HIV, and high CD8 count means that your body is effectively controlling the infection.

HIV infection was a deadly disease a few decades ago. People with untreated AIDS usually die within three years. With treatment and proper monitoring, people with HIV can live long and productive lives. 

CD4 counts, viral loads, and the CD4:CD8 ratio tests help your physician judge your disease control and fine-tune your treatment. Getting these tests done regularly will help you keep the infection under control.

                               HIV/AIDS

AIDS (acquired immunodeficiency syndrome) is a chronic, potentially life-threatening condition caused by the human immunodeficiency virus (HIV). By damaging your immune system, HIV interferes with your body's ability to fight the organisms that cause disease.

HIV is a sexually transmitted infection. It can also be spread by contact with infected blood or from mother to child during pregnancy, childbirth or breast-feeding. It can take years before HIV weakens your immune system to the point that you have AIDS.

Some drugists believe that there is no cure for HIV/AIDS, but other researchers believe that HIV/AIDs can be healed by boosting immune system. There are some medications that can dramatically slow disease progression. These medications have reduced AIDS deaths in many developed nations. But HIV continues to decimate populations in Africa, Haiti and parts of Asia.

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SYMPTOMS

The symptoms of HIV and AIDS vary, depending on the phase of infection.

Primary infection

The majority of people infected by HIV develop a flu-like illness within a month or two after the virus enters the body. This illness, known as primary or acute HIV infection, may last for a few weeks. Possible signs and symptoms include:

*Fever

*Headache

*Muscle aches

*Rash

*Chills

*Sore throat

*Mouth or genital ulcers

*Swollen lymph glands, mainly on the neck

*Joint pain

*Night sweats

*Diarrhea

Although the symptoms of primary HIV infection may be mild enough to go unnoticed, the amount of virus in the bloodstream (viral load) is particularly high at this time. As a result, HIV infection spreads more efficiently during primary infection than during the next stage of infection.

Clinical latent infection

In some people, persistent swelling of lymph nodes occurs during clinical latent HIV. Otherwise, there are no specific signs and symptoms. HIV remains in the body, however, and in infected white blood cells.

Clinical latent infection typically lasts eight to 10 years. A few people stay in this stage even longer, but others progress to more severe disease much sooner.

Early symptomatic HIV infection

As the virus continues to multiply and destroy immune cells, you may develop mild infections or chronic signs and symptoms such as:

*Fever

*Fatigue

*Swollen lymph nodes — often one of the first signs of HIV infection

*Diarrhea

*Weight loss

*Cough

*Shortness of breath

Progression to AIDS

If you receive no treatment for your HIV infection, the disease typically progresses to AIDS in about 10 years. By the time AIDS develops, your immune system has been severely damaged, making you susceptible to opportunistic infections — diseases that wouldn't trouble a person with a healthy immune system.

The signs and symptoms of some of these infections may include:

*Soaking night sweats

*Shaking chills or fever higher than 100 F (38 C) for several weeks

*Cough

*Shortness of breath

*Chronic diarrhea

*Persistent white spots or unusual lesions on your tongue or in your mouth

*Headaches

*Persistent, unexplained fatigue

*Blurred and distorted vision

*Weight loss

*Skin rashes or bumps

When can I see a doctor?

If you think you may have been infected with HIV or are at risk of contracting the virus, see a health care provider as soon as possible.

CAUSES

Scientists believe a virus similar to HIV first occurred in some populations of chimps and monkeys in Africa, where they're hunted for food. Contact with an infected monkey's blood during butchering or cooking may have allowed the virus to cross into humans and become HIV.

How does HIV become AIDS?

HIV destroys CD4 cells — a specific type of white blood cell that plays a large role in helping your body fight disease. Your immune system weakens as more CD4 cells are killed. You can have an HIV infection for years before it progresses to AIDS.

People infected with HIV progress to AIDS when their CD4 count falls below 200 or they experience an AIDS-defining complication, such as:

*Pneumocystis pneumonia

*Cytomegalovirus

*Tuberculosis

*Toxoplasmosis

*Cryptosporidiosis

How HIV is transmitted

To become infected with HIV, infected blood, semen or vaginal secretions must enter your body. You can't become infected through ordinary contact — hugging, kissing, dancing or shaking hands — with someone who has HIV or AIDS. HIV can't be transmitted through the air, water or via insect bites.

You can become infected with HIV in several ways, including:

*By having sex. You may become infected if you have vaginal, anal or oral sex with an infected partner whose blood, semen or vaginal secretions enter your body. The virus can enter your body through mouth sores or small tears that sometimes develop in the rectum or vagina during sexual activity.

*From blood transfusions. In some cases, the virus may be transmitted through blood transfusions. American hospitals and blood banks now screen the blood supply for HIV antibodies, so this risk is very small.

*By sharing needles. HIV can be transmitted through needles and syringes contaminated with infected blood. Sharing intravenous drug paraphernalia puts you at high risk of HIV and other infectious diseases, such as hepatitis.

*During pregnancy or delivery or through breast-feeding. Infected mothers can infect their babies. But receiving treatment for HIV infection during pregnancy, mothers significantly lower the risk to their babies.

RISK FACTORS

When HIV/AIDS first surfaced in the United States, it mainly affected men who had sex with men. However, now it's clear that HIV is also spread through heterosexual sex.

Anyone of any age, race, sex or sexual orientation can be infected, but you're at greatest risk of HIV/AIDS if you:

*Have unprotected sex. Unprotected sex means having sex without using a new latex or polyurethane condom every time. Anal sex is more risky than is vaginal sex. The risk increases if you have multiple sexual partners.

*Have another STI. Many sexually transmitted infections (STIs) produce open sores on your genitals. These sores act as doorways for HIV to enter your body.

*Use intravenous drugs. People who use intravenous drugs often share needles and syringes. This exposes them to droplets of other people's blood.

*Are an uncircumcised man. Studies indicate that lack of circumcision increases the risk of heterosexual transmission of HIV.

COMPLICATIONS

HIV infection weakens your immune system, making you highly susceptible to numerous infections and certain types of cancers.

Infections common to HIV/AIDS

#Tuberculosis (TB). In resource-poor nations, TB is the most common opportunistic infection associated with HIV and a leading cause of death among people with AIDS. Millions of people are currently infected with both HIV and tuberculosis, and many experts consider the two diseases to be twin epidemics.

#Salmonellosis. You contract this bacterial infection from contaminated food or water. Signs and symptoms include severe diarrhea, fever, chills, abdominal pain and, occasionally, vomiting. Although anyone exposed to salmonella bacteria can become sick, salmonellosis is far more common in HIV-positive people.

#Cytomegalovirus. This common herpes virus is transmitted in body fluids such as saliva, blood, urine, semen and breast milk. A healthy immune system inactivates the virus, and it remains dormant in your body. If your immune system weakens, the virus resurfaces — causing damage to your eyes, digestive tract, lungs or other organs.

#Candidiasis. Candidiasis is a common HIV-related infection. It causes inflammation and a thick, white coating on the mucous membranes of your mouth, tongue, esophagus or vagina. Children may have especially severe symptoms in the mouth or esophagus, which can make eating painful.

#Cryptococcal meningitis. Meningitis is an inflammation of the membranes and fluid surrounding your brain and spinal cord (meninges). Cryptococcal meningitis is a common central nervous system infection associated with HIV, caused by a fungus found in soil. The disease may also be associated with bird or bat droppings.

#Toxoplasmosis. This potentially deadly infection is caused by Toxoplasma gondii, a parasite spread primarily by cats. Infected cats pass the parasites in their stools, and the parasites may then spread to other animals and humans.

#Cryptosporidiosis. This infection is caused by an intestinal parasite that's commonly found in animals. You contract cryptosporidiosis when you ingest contaminated food or water. The parasite grows in your intestines and bile ducts, leading to severe, chronic diarrhea in people with AIDS.

Cancers common to HIV/AIDS

#Kaposi's sarcoma. A tumor of the blood vessel walls, this cancer is rare in people not infected with HIV, but common in HIV-positive people.

Kaposi's sarcoma usually appears as pink, red or purple lesions on the skin and mouth. In people with darker skin, the lesions may look dark brown or black. Kaposi's sarcoma can also affect the internal organs, including the digestive tract and lungs.

#Lymphomas. This type of cancer originates in your white blood cells and usually first appears in your lymph nodes. The most common early sign is painless swelling of the lymph nodes in your neck, armpit or groin.

Other complications

*Wasting syndrome. Aggressive treatment regimens have reduced the number of cases of wasting syndrome, but it still affects many people with AIDS. It's defined as a loss of at least 10 percent of body weight, often accompanied by diarrhea, chronic weakness and fever.

*Neurological complications. Although AIDS doesn't appear to infect the nerve cells, it can cause neurological symptoms such as confusion, forgetfulness, depression, anxiety and difficulty walking. One of the most common neurological complications is AIDS dementia complex, which leads to behavioral changes and diminished mental functioning.

*Kidney disease. HIV-associated nephropathy (HIVAN) is an inflammation of the tiny filters in your kidneys that remove excess fluid and wastes from your bloodstream and pass them to your urine. Because of a genetic predisposition, the risk of developing HIVAN is much higher in blacks.

Regardless of CD4 count, antiretroviral therapy should be started in those diagnosed with HIVAN.

PREPARING FOR YOUR APPOINTMENT

If you think you might have HIV infection, you're likely to start by seeing your family doctor. You may be referred to an infectious disease specialist.

What you can do

Before your appointment, you might want to write a list answering the following questions:

*How do you think you were exposed to HIV?

*What are your symptoms?

*Do you have risk factors, such as participating in unprotected anal sex or using intravenous drugs?

*What prescription drugs or supplements do you take?

What you can do in the meantime

If you think you might have HIV infection, there are some precautions you can take to protect yourself and others before your appointment.

Have only protected sexual intercourse. Inject drugs with a clean needle only, and don't share it with others.

TESTS AND DIAGNOSIS

HIV is most commonly diagnosed by testing your blood or saliva for antibodies to the virus. Unfortunately, it takes time for your body to develop these antibodies — usually up to 12 weeks. In rare cases, it can take up to six months for an HIV antibody test to become positive.

A newer type of test that checks for HIV antigen, a protein produced by the virus immediately after infection, can confirm a diagnosis within days of infection. An earlier diagnosis may prompt people to take extra precautions to prevent transmission of the virus to others. There is also increasing evidence that early treatment may be of benefit.

Tests to tailor treatment

If you receive a diagnosis of HIV/AIDS, several types of tests can help your doctor determine what stage of the disease you have. These tests include:

*CD4 count. CD4 cells are a type of white blood cell that's specifically targeted and destroyed by HIV. A healthy person's CD4 count can vary from 500 to more than 1,000. Even if you have no symptoms, HIV infection progresses to AIDS when your CD4 count dips below 200.

*Viral load. This test measures the amount of virus in your blood. Studies have shown that people with higher viral loads generally fare more poorly than do those with a lower viral load.

*Drug resistance. This blood test determines whether the strain of HIV you have will be resistant to certain anti-HIV medications.

Tests for complications

Your doctor might also order lab tests to check for other infections or complications, including:

*Tuberculosis

*Hepatitis

*Toxoplasmosis

*Sexually transmitted infections

*Liver or kidney damage

*Urinary tract infection

TREATMENTS

There's no cure for HIV/AIDS, but a variety of drugs can be used in combination to control the virus. Each class of anti-HIV drugs blocks the virus in different ways. It's best to combine at least three drugs from two classes to avoid creating strains of HIV that are immune to single drugs.

When to start treatment

Guidelines from the Department of Health and Human Services recommend that everyone with HIV infection, regardless of CD4 count, be offered antiviral medication. However, some experts question the guidelines because of concerns about long-term toxicity of these drugs, drug resistance, cost and difficulty adhering to the drug regime.

You should definitely begin treatment, however, if:

*You have severe symptoms

*You have an opportunistic infection

*Your CD4 count is under 350, You're pregnant

*You have HIV-related kidney disease

*You're being treated for hepatitis B

Treatment can be difficult

HIV treatment regimens may involve taking multiple pills at specific times every day for the rest of your life. Side effects can include:

*Nausea, vomiting or diarrhea

*Heart disease

*Weakened bones

*Shortness of breath

*Skin rash

*Bone death, particularly in the hip joints

Codiseases and cotreatments

Some health issues that are a natural part of aging may be more difficult to manage if you have HIV. Some medications that are common for age-related cardiovascular, metabolic and bone conditions, for example, may not interact well with anti-HIV medications. Talk to your doctor about other conditions for which you're taking medication.

Treatment response

Your doctor will monitor your viral load and CD4 counts to determine your response to treatment. Viral load should be tested at the start of treatment and then every three to four months during therapy. CD4 counts should be checked every three to six months.

HIV treatment should reduce your viral load to the point that it's undetectable. That doesn't mean your HIV is gone. It just means that the test isn't sensitive enough to detect it. You can still transmit HIV to others when your viral load is undetectable.

LIFESTYLE AND HOME REMEDIES

There's no vaccine to prevent HIV infection and no cure for AIDS. But it's possible to protect yourself and others from infection. That means educating yourself about HIV and avoiding any behavior that allows HIV-infected fluids — blood, semen, vaginal secretions and breast milk — into your body.

To help prevent the spread of HIV:

*Use a new condom every time you have sex. If you don't know the HIV status of your partner, use a new condom every time you have anal or vaginal sex. Women can use a female condom. Use only water-based lubricants. Oil-based lubricants can weaken condoms and cause them to break. During oral sex use a condom, dental dam — a piece of medical-grade latex — or plastic wrap.

*Consider some drugs and Herbal medicines. In July 2012, the Food and Drug Administration(FDA) approved the use of the combination of some medicines to reduce the risk of sexually transmitted HIV infection in those who are at high risk. 

*Tell your sexual partners if you have HIV. It's important to tell anyone with whom you've had sex that you're HIV-positive. Your partners need to be tested and to receive medical care if they have the virus. They also need to know their HIV status so that they don't infect others.

*Use a clean needle. If you use a needle to inject drugs, make sure it's sterile and don't share it. Take advantage of needle-exchange programs in your community and consider seeking help for your drug use.

*If you're pregnant, get medical care right away. If you're HIV-positive, you may pass the infection to your baby. But if you receive treatment during pregnancy, you can cut your baby's risk by as much as two-thirds.

*Consider male circumcision. There's evidence that male circumcision can help reduce a man's risk of acquiring HIV.

ALTERNATIVE MEDICINE

People who are infected with HIV sometimes try dietary supplements that claim to boost the immune system or counteract side effects of anti-HIV.

*Try to boost your immune system. Sometimes by boosting immune system can treat HIV/AIDs especially by using some Herbal medicines though not approved by Food and Drug Administration. Because some Herbal medicines are considered as Food supplements to boost immune system and heal some diseases. Boosting immune system simply means increasing White blood cells also known as Soldiers of the body. But during the course, don't stop taking Drugs approved by FDA till you are tested negative. Consume more Immune boosters for you to get best results. 

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#16/24 Off Zambezi road,

Email: mtongaisaacpharmacy@gmail.com,

Tel: +260974272433/ +260966399444,

Lusaka, Zambia.

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